IDD : Institute For Diabetes Discovery

We publish to follow a credible scientific and academic tradition that validates our work, provides peer review and allows us to share our learning with the wider community in diabetes research. We offer the opportunity to download the following starred publications.

Chiesa R, Noguera I and Sredy J: (1997) Phosphorylation of HSP24 during lens cell differentiation. Exp Eye Res 65, 223-229.

* Jacot JL and Sredy J: (1999) Emerging therapeutics for diabetic retinopathy: potential therapies for the new millennium. (226k PDF) Emergering Therapeutic Targets 3 (2), 307-335.

GLYCATION

* Piotrowski M, Haigh B, and Litchfield J: (1998) ESI-LC/MS analysis of a non-enzymatically glycated albumin peptide: A novel glycation assay. (36k PDF) Journal American Society for Mass Spectrometry 9, 4, 383.

* Haigh B, Piotrowski M, and Litchfield, J: (1998) Analysis of a non-enzymatically glycated albumin peptide: A novel LC/MS glycation assay. (35k PDF) Diabetes 47, S1, A370.

Jacot JL, Knowles WJ, Carrington AL, Litchfield JE, Orlowski LS, Haigh B, and Sredy J: (1999) Localization of early glycation products in ocular tissues of streptozotocin-induced diabetic rats. IOVS 40, 4, S446.

* Carrington A, Orlowski L, Cannan S, Letsinger J, Haigh B, and Litchfield J, (1999) Increased glycation and nerve dysfunction in experimental diabetes. (35k PDF) Journal American Society for Mass Spectrometry 4:2:193.

Carrington A and Litchfield J: (1999) The aldose reductase pathway and nonenzymatic glycation in the pathogenesis of diabetic neuropathy: A critical review for the end of the 20th century. Diabetes Reviews vol. 7, no. 4, 275-299.

* Jacot J, Knowles W, Carrington A, Litchfield J, Haigh B, and Sredy J. (1998) Increased Amadori-modified proteins in ocular tissue of streptozocin-induced diabetic rats. (569k PDF) Diabetic Complications Conference, Joslin Diabetes Center, October 1998.

* Litchfield J, Letsinger J, Haigh B, Guralski D, Carrington AL, Cannan S, and Sredy J: (1998) Non-enzymatic glycation of plasma and cellular proteins in a short term STZ-diabetic rat model. (391k PDF) Diabetologia 41, S1, A301.

IDD 676

* Lavoie DJ, Jacot JL, Knowles WJ, Carrington AL, Litchfield JE, Haigh B, and Sredy J: (1999) Characterization of Amadori-modified proteins in ocular tissues of experimental diabetic rats. (55k PDF) IOVS 40, 4, S607.

Rogniaux, H.; Van Dorsselaer, A.; Barth, P.; Biellmann, J. F.; Barbanton, J.; Van Zandt, M.; Chevrier, B.; Howard, E.; Mitschler, A.; Potier, N.; Urzhumtseva, L.; Moras, D.; Podjarny, A. Laboratoire de Spectrometrie de Masse Bio-Organique, Institut de Chimie, Universite Louis Pasteur, Strasbourg, Fr. (1999) Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies. Journal American Society for Mass Spectrometry 10(7), 635-647.

Cachau, R.; Howard, E.; Barth, P.; Mitschler, A.; Chevrier, B.; Lamour, V.; Joachimiak, A.; Sanishvili, R.; Van Zandt, M.; Sibley, E.; Moras, D.; Podjarny, A. (2000) Model of the catalytic mechanism of human aldose reductase based on quantum chemical calculations. UPR de Biologie Structurale, IGBMC, Illkirch, Fr. J. Phys. IV, 10.

Jones, J. Howard; Gunn, David; Jones, Michael Lee; Van Zandt, Michael C.; Lavoie, Danny J.; Sawicki, Diane; Sredy, Janet; Howard, Eduardo; Podjarny, Alberto D. (2000) Substituted indolealkanoic acids as novel aldose reductase inhibitors. Institute for Diabetes Discovery, Branford, CT, USA. Abstr. Pap. - Am. Chem. Soc. 220th MEDI-307.

* Calderone, Vito; Chevrier, Bernard; Van Zandt, Michael; Lamour, Valerie; Howard, Eduardo; Poterszman, Arnaud; Barth, Patrick; Mitschler, Andre; Lu, Jianhui; Dvornik, Dushan M.; Klebe, Gerhard; Kraemer, Oliver; Moorman, Allan R.; Moras, Dino; Podjarny, Alberto. (2000) The structure of human aldose reductase bound to the inhibitor IDD384. UPR de Biologie Structurale 9004, IGBMC, CNRS/INSERM/ULP, Illkirch, Fr. Acta Crystallographica Section D, Biological Crystallography D56: 536-540.

* Van Zandt, Michael C.; Sibley, Evelyn O.; Combs, Kerry J.; McCann, Erin E.; Flam, Brenda; Lavoie, Danny J.; Sawicki, Diane; Sabetta, Al; Carrington, Anne; Sredy, Janet; Calderone, Vito; Cuevrier, Bernard; Podjarny, Alberto. (1999) Design and synthesis of novel inhibitors of aldose reductase for the treatment of diabetic complications. (685k PDF) Institute for Diabetes Discovery, Inc., Branford, CT, and USA. Book of Abstracts, 218th ACS National Meeting, New Orleans, Aug. 22-26 (1999), MEDI-137. Publisher: American Chemical Society, Washington, D. C.

Carrington, A, Cannan S, Smiarowski H, Lavoie D, Sawicki D, Sabetta A, Litchfield J, VanZandt M, and Sredy J: (1999) IDD 676, A potent aldose reductase specific inhibitor prevents nerve dysfunction in experimental diabetes. Diabetologia 42, S1, A293.

OBESITY

Ambrosini, G., Nath, A., Sierra-Honigmann, M., Flores-Riveros, J. (2000, December). Leptin Expression is Transcriptionally Regulated by Hypoxia and Requires Hypoxia-inductible Factor 1 (HIF-1). Poster session presented at the American Society for Cell Biology, San Francisco.

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